A Physiologically-Motivated Compartment-Based Model of the Effect of Inhaled Hypertonic Saline on Mucociliary Clearance and Liquid Transport in Cystic Fibrosis

BACKGROUND: Cystic Fibrosis (CF) lung disease is characterized by liquid hyperabsorption, airway surface dehydration, and impaired mucociliary clearance (MCC). Herein, we present a compartment-based mathematical model of the airway that extends the resolution of functional imaging data. METHODS: Usi...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Markovetz, Matthew R., Corcoran, Timothy E., Locke, Landon W., Myerburg, Michael M., Pilewski, Joseph M., Parker, Robert S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226497/
https://ncbi.nlm.nih.gov/pubmed/25383714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0111972
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