Evaluation of Exogenous siRNA Addition as a Metabolic Engineering Tool for Modifying Biopharmaceuticals

Traditional metabolic engineering approaches, including homologous recombination, zinc finger nucleases, and short hairpin RNA (shRNA), have previously been employed to generate biologics with specific characteristics that improve efficacy, potency, and safety. An alternative approach is to exogenou...

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Detalhes bibliográficos
Publicado no:Biotechnol Prog
Main Authors: Tummala, Seshu, Titus, Michael, Wilson, Lee, Wang, Chunhua, Ciatto, Carlo, Foster, Donald, Szabo, Zoltan, Guttman, Andras, Li, Chen, Bettencourt, Brian, Jayaraman, Muthuswamy, Deroot, Jack, Thill, Greg, Kocisko, David, Pollard, Stuart, Charisse, Klaus, Kuchimanchi, Satya, Hinkle, Greg, Milstein, Stuart, Myers, Rachel, Wu, Shiaw-Lin, Karger, Barry, Rossomando, Anthony
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226405/
https://ncbi.nlm.nih.gov/pubmed/23172735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/btpr.1667
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