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Transplantation of prokaryotic two-component signaling pathways into mammalian cells
Signaling pathway engineering is a promising route toward synthetic biological circuits. Histidine–aspartate phosphorelays are thought to have evolved in prokaryotes where they form the basis for two-component signaling. Tyrosine-serine–threonine phosphorelays, exemplified by MAP kinase cascades, ar...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4226098/ https://ncbi.nlm.nih.gov/pubmed/25331891 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1406482111 |
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