An intramolecular lock facilitates folding and stabilizes the tertiary structure of Streptococcus mutans adhesin P1

The cariogenic bacterium Streptococcus mutans uses adhesin P1 to adhere to tooth surfaces, extracellular matrix components, and other bacteria. A composite model of P1 based on partial crystal structures revealed an unusual complex architecture in which the protein forms an elongated hybrid alpha/po...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Heim, Kyle P., Crowley, Paula J., Long, Joanna R., Kailasan, Shweta, McKenna, Robert, Brady, L. Jeannine
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2014
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226092/
https://ncbi.nlm.nih.gov/pubmed/25331888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1413018111
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