Pathogenic autoantibodies from patients with lupus nephritis cause reduced tyrosine phosphorylation of podocyte proteins, including tubulin

INTRODUCTION: The tertiary structure of normal podocytes prevents protein from leaking into urine. Patients with lupus nephritis (LN) develop proteinuria, and kidney biopsies from these patients display a number of podocyte abnormalities including retraction of podocyte processes. Autoantibodies hav...

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Detalhes bibliográficos
Publicado no:Lupus Sci Med
Main Authors: Manson, Jessica J, Mills, Kevin, Jury, Elizabeth, Mason, Lesley, D'Cruz, David P, Ni, Lan, Saleem, Moin, Mathieson, Peter, Isenberg, David, Rahman, Anisur
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2014
Assuntos:
Lupus Nephritis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4225730/
https://ncbi.nlm.nih.gov/pubmed/25396061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/lupus-2014-000013
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