Insulin, Insulin-like Growth Factor-I, Endogenous Estradiol, and Risk of Colorectal Cancer in Postmenopausal Women

Obesity is a risk factor for colorectal cancer, and hyperinsulinemia, a common condition in obese patients, may underlie this relationship. Insulin, in addition to its metabolic effects, has promitotic and antiapoptotic activity that may be tumorigenic. Insulin-like growth factor (IGF)-I, a related...

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Publicado no:Cancer Res
Main Authors: Gunter, Marc J., Hoover, Donald R., Yu, Herbert, Wassertheil-Smoller, Sylvia, Rohan, Thomas E., Manson, JoAnn E., Howard, Barbara V., Wylie-Rosett, Judith, Anderson, Garnet L., Ho, Gloria Y.F., Kaplan, Robert C., Li, Jixin, Xue, Xiaonan, Harris, Tiffany G., Burk, Robert D., Strickler, Howard D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4225702/
https://ncbi.nlm.nih.gov/pubmed/18172327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-2946
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