Chronic DPP-4 Inhibition Reduces Atherosclerosis and Inflammation via Effects on Monocyte Recruitment and Chemotaxis

BACKGROUND: DPP-4 inhibitors are increasingly used to accomplish glycemic targets in patients with Type II diabetes (T2DM). Since DPP-4 is expressed in inflammatory cells, we hypothesized that its inhibition will exert favorable effects in atherosclerosis. METHODS AND RESULTS: Male LDLR(-/-) mice (6...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Circulation
Huvudupphovsmän: Shah, Zubair, Kampfrath, Thomas, Deiuliis, Jeffrey A., Zhong, Jixin, Pineda, Colleen, Ying, Zhekang, Xu, Xiaohua, Lu, Bo, Moffatt-Bruce, Susan, Durairaj, Rekha, Sun, Qinghua, Mihai, Georgeta, Maiseyeu, Andrei, Rajagopalan, Sanjay
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224594/
https://ncbi.nlm.nih.gov/pubmed/22007077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.111.041418
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk