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Reduction of T Cell Receptor Diversity in NOD Mice Prevents Development of Type 1 Diabetes but Not Sjögren’s Syndrome

Non-obese diabetic (NOD) mice are well-established models of independently developing spontaneous autoimmune diseases, Sjögren’s syndrome (SS) and type 1 diabetes (T1D). The key determining factor for T1D is the strong association with particular MHCII molecule and recognition by diabetogenic T cell...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kern, Joanna, Drutel, Robert, Leanhart, Silvia, Bogacz, Marek, Pacholczyk, Rafal
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224485/
https://ncbi.nlm.nih.gov/pubmed/25379761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0112467
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