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3D Cultures of Prostate Cancer Cells Cultured in a Novel High-Throughput Culture Platform Are More Resistant to Chemotherapeutics Compared to Cells Cultured in Monolayer

Despite monolayer cultures being widely used for cancer drug development and testing, 2D cultures tend to be hypersensitive to chemotherapy and are relatively poor predictors of whether a drug will provide clinical benefit. Whilst generally more complicated, three dimensional (3D) culture systems of...

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Опубликовано в: :PLoS One
Главные авторы: Chambers, Karen F., Mosaad, Eman M. O., Russell, Pamela J., Clements, Judith A., Doran, Michael R.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2014
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224379/
https://ncbi.nlm.nih.gov/pubmed/25380249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0111029
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