OVOL2 is a critical regulator of ER71/ETV2 in generating FLK1(+), hematopoietic, and endothelial cells from embryonic stem cells

In this study, we report that OVOL2, a C(2)H(2) zinc finger protein, is a novel binding protein of ER71, which is a critical transcription factor for blood and vessel development. OVOL2 directly interacted with ER71, but not with ETS1 or ETS2, in the nucleus. ER71-mediated activation of the Flk1 pro...

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Veröffentlicht in:Blood
Hauptverfasser: Kim, Ju Young, Lee, Ra Ham, Kim, Tae Min, Kim, Dong-Wook, Jeon, Young-Joo, Huh, Sung-Ho, Oh, Se-Yeong, Kyba, Michael, Kataoka, Hiroshi, Choi, Kyunghee, Ornitz, David M., Chae, Jung-Il, Park, Changwon
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2014
Schlagworte:
Hematopoiesis and Stem Cells
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224193/
https://ncbi.nlm.nih.gov/pubmed/25267199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-03-556332
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