Biomaterial arrays with defined adhesion ligand densities and matrix stiffness identify distinct phenotypes for tumorigenic and nontumorigenic human mesenchymal cell types

Here, we aimed to investigate migration of a model tumor cell line (HT-1080 fibrosarcoma cells, HT-1080s) using synthetic biomaterials to systematically vary peptide ligand density and substrate stiffness. A range of substrate elastic moduli were investigated by using poly(ethylene glycol) (PEG) hyd...

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Veröffentlicht in:Biomater Sci
Hauptverfasser: Hansen, Tyler D., Koepsel, Justin T., Le, Ngoc Nhi, Nguyen, Eric H., Zorn, Stefan, Parlato, Matthew, Loveland, Samuel G., Schwartz, Michael P., Murphy, William L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224020/
https://ncbi.nlm.nih.gov/pubmed/25386339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C3BM60278H
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