Disruption of endothelial adherens junctions by high glucose is mediated by protein kinase C-β–dependent vascular endothelial cadherin tyrosine phosphorylation

BACKGROUND: Hyperglycemia has been recognized as a primary factor in endothelial barrier dysfunction and in the development of micro- and macrovascular diseases associated with diabetes, but the underlying biochemical mechanisms remain elusive. Tyrosine phosphorylation of vascular endothelial cadher...

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Опубликовано в: :Cardiovasc Diabetol
Главные авторы: Haidari, Mehran, Zhang, Wei, Willerson, James T, Dixon, Richard AF
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2014
Предметы:
Original Investigation
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4223716/
https://ncbi.nlm.nih.gov/pubmed/25927959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2840-13-105
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