Psychiatric risk factor ANK3/Ankyrin-G nanodomains regulate the structure and function of glutamatergic synapses

Recent evidence implicates glutamatergic synapses as key pathogenic sites in psychiatric disorders. Common and rare variants in the ANK3 gene, encoding ankyrin-G, have been associated with bipolar disorder, schizophrenia, and autism. Here we demonstrate that ankyrin-G is integral to AMPAR-mediated s...

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Publicado no:Neuron
Main Authors: Smith, Katharine R., Kopeikina, Katherine J., Fawcett-Patel, Jessica M., Leaderbrand, Katherine, Gao, Ruoqi, Schürmann, Britta, Myczek, Kristoffer, Radulovic, Jelena, Swanson, Geoffrey T., Penzes, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4223651/
https://ncbi.nlm.nih.gov/pubmed/25374361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.10.010
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