PP242 suppresses cell proliferation, metastasis, and angiogenesis of gastric cancer through inhibition of the PI3K/AKT/mTOR pathway

Although preclinical work with rapalogs suggests potential in the treatment of gastric cancer, they have been less successful clinically. In this study, we report the impact of the investigational drug PP242, a potent and selective small-molecule active-site TORC1/2 kinase inhibitor, on tumor growth...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Anticancer Drugs
Autori principali: Xing, Xiaofang, Zhang, Lianhai, Wen, Xianzi, Wang, Xiaohong, Cheng, Xiaojing, Du, Hong, Hu, Ying, Li, Lin, Dong, Bin, Li, Ziyu, Ji, Jiafu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Lippincott Williams & Wilkins 2014
Soggetti:
Preclinical Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4222793/
https://ncbi.nlm.nih.gov/pubmed/25035961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CAD.0000000000000148
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