PP242 suppresses cell proliferation, metastasis, and angiogenesis of gastric cancer through inhibition of the PI3K/AKT/mTOR pathway

Although preclinical work with rapalogs suggests potential in the treatment of gastric cancer, they have been less successful clinically. In this study, we report the impact of the investigational drug PP242, a potent and selective small-molecule active-site TORC1/2 kinase inhibitor, on tumor growth...

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Библиографические подробности
Опубликовано в: :Anticancer Drugs
Главные авторы: Xing, Xiaofang, Zhang, Lianhai, Wen, Xianzi, Wang, Xiaohong, Cheng, Xiaojing, Du, Hong, Hu, Ying, Li, Lin, Dong, Bin, Li, Ziyu, Ji, Jiafu
Формат: Artigo
Язык:Inglês
Опубликовано: Lippincott Williams & Wilkins 2014
Предметы:
Preclinical Reports
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4222793/
https://ncbi.nlm.nih.gov/pubmed/25035961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CAD.0000000000000148
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