Llwytho...

Fast, label-free force spectroscopy of histone-DNA interactions in individual nucleosomes using nanopores

Herein we report a novel approach for fast, label-free probing of DNA-histone interactions in individual nucleosomes. We use solid-state nanopores to unravel individual DNA/histone complexes for the first time, and find that the unraveling time depends on the applied electrophoretic force, and our r...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Am Chem Soc
Prif Awduron: Ivankin, Andrey, Carson, Spencer, Kinney, Shannon R. M., Wanunu, Meni
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4221845/
https://ncbi.nlm.nih.gov/pubmed/24079416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja408354s
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