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Fast, label-free force spectroscopy of histone-DNA interactions in individual nucleosomes using nanopores
Herein we report a novel approach for fast, label-free probing of DNA-histone interactions in individual nucleosomes. We use solid-state nanopores to unravel individual DNA/histone complexes for the first time, and find that the unraveling time depends on the applied electrophoretic force, and our r...
Gardado en:
| Publicado en: | J Am Chem Soc |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4221845/ https://ncbi.nlm.nih.gov/pubmed/24079416 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja408354s |
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