Zolpidem Reduces Hippocampal Neuronal Activity in Freely Behaving Mice: A Large Scale Calcium Imaging Study with Miniaturized Fluorescence Microscope

Therapeutic drugs for cognitive and psychiatric disorders are often characterized by their molecular mechanism of action. Here we demonstrate a new approach to elucidate drug action on large-scale neuronal activity by tracking somatic calcium dynamics in hundreds of CA1 hippocampal neurons of pharma...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Berdyyeva, Tamara, Otte, Stephani, Aluisio, Leah, Ziv, Yaniv, Burns, Laurie D., Dugovic, Christine, Yun, Sujin, Ghosh, Kunal K., Schnitzer, Mark J., Lovenberg, Timothy, Bonaventure, Pascal
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4221229/
https://ncbi.nlm.nih.gov/pubmed/25372144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0112068
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