Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients

Here, we demonstrate that electroporation-enhanced immunization with a rationally designed HPV DNA vaccine (GX-188E), preferentially targeting HPV antigens to dendritic cells, elicits a significant E6/E7-specific IFN-γ-producing T-cell response in all nine cervical intraepithelial neoplasia 3 (CIN3)...

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Publicado en:Nat Commun
Autores principales: Kim, Tae Jin, Jin, Hyun-Tak, Hur, Soo-Young, Yang, Hyun Gul, Seo, Yong Bok, Hong, Sung Ran, Lee, Chang-Woo, Kim, Suhyeon, Woo, Jung-Won, Park, Ki Seok, Hwang, Youn-Young, Park, Jaehan, Lee, In-Ho, Lim, Kyung-Taek, Lee, Ki-Heon, Jeong, Mi Seon, Surh, Charles D., Suh, You Suk, Park, Jong Sup, Sung, Young Chul
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Pub. Group 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4220493/
https://ncbi.nlm.nih.gov/pubmed/25354725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6317
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