Deletion and deletion/insertion mutations in the juxtamembrane domain of the FLT3 gene in adult acute myeloid leukemia

In contrast to FLT3 ITD mutations, in-frame deletions in the FLT3 gene have rarely been described in adult acute leukemia. We report two cases of AML with uncommon in-frame mutations in the juxtamembrane domain of the FLT3 gene: a 3-bp (c.1770_1774delCTACGinsGT; p.F590_V592delinsLF) deletion/inserti...

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Detalhes bibliográficos
Publicado no:Leuk Res Rep
Main Authors: Deeb, Kristin K., Smonskey, Matthew T., DeFedericis, HanChun, Deeb, George, Sait, Sheila N.J., Wetzler, Meir, Wang, Eunice S., Starostik, Petr
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
Assuntos:
Case Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4220013/
https://ncbi.nlm.nih.gov/pubmed/25379410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lrr.2013.09.003
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