A Phylogeny-Based Benchmarking Test for Orthology Inference Reveals the Limitations of Function-Based Validation

Accurate orthology prediction is crucial for many applications in the post-genomic era. The lack of broadly accepted benchmark tests precludes a comprehensive analysis of orthology inference. So far, functional annotation between orthologs serves as a performance proxy. However, this violates the fu...

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Udgivet i:PLoS One
Main Authors: Trachana, Kalliopi, Forslund, Kristoffer, Larsson, Tomas, Powell, Sean, Doerks, Tobias, von Mering, Christian, Bork, Peer
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4219706/
https://ncbi.nlm.nih.gov/pubmed/25369365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0111122
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