Innate immunity but not NLRP3 inflammasome activation correlates with severity of stable COPD

BACKGROUND: In models of COPD, environmental stressors induce innate immune responses, inflammasome activation and inflammation. However, the interaction between these responses and their role in driving pulmonary inflammation in stable COPD is unknown. OBJECTIVES: To investigate the activation of i...

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Dettagli Bibliografici
Pubblicato in:Thorax
Autori principali: Di Stefano, Antonino, Caramori, Gaetano, Barczyk, Adam, Vicari, Chiara, Brun, Paola, Zanini, Andrea, Cappello, Francesco, Garofano, Elvira, Padovani, Anna, Contoli, Marco, Casolari, Paolo, Durham, Andrew L, Chung, Kian Fan, Barnes, Peter J, Papi, Alberto, Adcock, Ian, Balbi, Bruno
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Publishing Group 2014
Soggetti:
Chronic Obstructive Pulmonary Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4219154/
https://ncbi.nlm.nih.gov/pubmed/24430176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2012-203062
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