Innate immunity but not NLRP3 inflammasome activation correlates with severity of stable COPD

BACKGROUND: In models of COPD, environmental stressors induce innate immune responses, inflammasome activation and inflammation. However, the interaction between these responses and their role in driving pulmonary inflammation in stable COPD is unknown. OBJECTIVES: To investigate the activation of i...

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Bibliographic Details
Published in:Thorax
Main Authors: Di Stefano, Antonino, Caramori, Gaetano, Barczyk, Adam, Vicari, Chiara, Brun, Paola, Zanini, Andrea, Cappello, Francesco, Garofano, Elvira, Padovani, Anna, Contoli, Marco, Casolari, Paolo, Durham, Andrew L, Chung, Kian Fan, Barnes, Peter J, Papi, Alberto, Adcock, Ian, Balbi, Bruno
Format: Artigo
Language:Inglês
Published: BMJ Publishing Group 2014
Subjects:
Chronic Obstructive Pulmonary Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4219154/
https://ncbi.nlm.nih.gov/pubmed/24430176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2012-203062
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