Lipocortin 1 mediates the inhibition by dexamethasone of the induction by endotoxin of nitric oxide synthase in the rat.

Administration of Escherichia coli lipopolysaccharide (LPS; 10 mg/kg i.v.) to male Wistar rats caused within 240 min (i) a sustained fall (approximately 30 mmHg) in mean arterial blood pressure, (ii) a reduction (> 75%) in the pressor responses to norepinephrine (1 microgram/kg i.v.), and (iii) an i...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Wu, C C, Croxtall, J D, Perretti, M, Bryant, C E, Thiemermann, C, Flower, R J, Vane, J R
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1995
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42189/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7536934/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.8.3473
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