PL-02 NOTCH-MEDIATED SUPPRESSION OF MULTICILIATE DIFFERENTIATION PROMOTES CHOROID PLEXUS TUMOR INITIATION FROM EPITHELIAL PROGENITOR IN RESPONSE TO Shh SIGNALS

Choroid plexus (CP) tumors are intraventricular papillary neoplasms mainly found in children. While CP papilloma is a benign tumor, CP carcinoma is malignant and associated with poor prognosis. Though previous studies implicate Notch signaling in CP tumorigenesis, the developmental origin and mechan...

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Publicado en:Neuro Oncol
Main Authors: Li, Li, Picotte, Katie, Ohli, Jasmin, Schüller, Ulrich, Zhao, Haotian
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218468/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou267.2
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