IT-09 PHASE I STUDY OF SAFETY, TOLERABILITY AND IMMUNOLOGIC EFFECTS OF A SURVIVIN PEPTIDE MIMIC VACCINE (SurVaxM) IN PATIENTS WITH RECURRENT MALIGNANT GLIOMA

BACKGROUND: Survivin is an inhibitor of apoptosis protein (IAP) that is highly expressed in malignant gliomas and other cancers. Induction of cytotoxic immunity against survivin is an attractive antitumor strategy. Preclinical studies demonstrated the ability of a KLH-conjugated survivin peptide mim...

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Hauptverfasser: Fenstermaker, Robert, Mechtler, Laszlo, Qiu, Jingxin, Mogensen, Kathleen, Ahluwalia, Manmeet, Adjei, Alex, Lee, Kelvin, Ciesielski, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218258/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou258.7
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