CS-05 MUTATION SPECIFIC FUNCTIONS OF EGFR RESULT IN A MUTATION-SPECIFIC DOWNSTREAM PATHWAY ACTIVATION

BACKGROUND: EGFR is frequently mutated in various types of cancer. Although all oncogenic mutations are considered activating, different tumor types have different mutation spectra. It is possible that functional differences underlie this tumor-type specific mutation spectrum. METHODS: We have deter...

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Main Authors: Erdem-Eraslan, Lale, Gao, Ya, Kloosterhof, Nanne, Atlasi, Yaser, Demmers, Jeroen, Sacchetti, Andrea, Kros, Johan, Smitt, Peter Sillevis, Aerts, Joachim, French, Pim
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217998/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou242.5
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