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AI-16 HIF-1a INHIBITION BY RNA INTERFERENCE DELIVERED VIA A NOVEL MULTIFUNCTIONAL SURFACTANT ATTENUATES GLIOMA GROWTH IN AN INTRACRANIAL MOUSE MODEL
INTRODUCTION: Glioblastoma is the most common and deadliest form of adult brain cancer with a dismal prognosis despite aggressive therapeutic measures. Intratumoral hypoxia is thought to be a main contributor to tumorigenesis and angiogenesis of these tumors. Since Hif-1α the major mediator of hypox...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
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Oxford University Press
2014
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| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4217854/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou238.16 |
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