AT-58 JCOG0911 INTEGRA TRIAL: A RANDOMIZED SCREENING PHASE II TRIAL OF CHEMORADIOTHERAPY WITH INTERFERONβ PLUS TEMOZOLOMIDE VERSUS CHEMORADIOTHERAPY WITH TEMOZOLOMIDE ALONE FOR NEWLY-DIAGNOSED GLIOBLASTOMA

BACKGROUND: Our lab experiments showed that interferonβ (IFNβ) markedly enhanced chemosensitivity to temozolomide (TMZ) via the down-regulation of MGMT transcription. Followed by phase I trial, INTEGRA trial investigated the efficacy of TMZ + IFNβ therapy by a randomized screening design as compared...

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Bibliographische Detailangaben
Veröffentlicht in:Neuro Oncol
Hauptverfasser: Wakabayashi, Toshihiko, Natsume, Atsushi, Mizusawa, Junki, Katayama, Hiroshi, Fukuda, Haruhiko, Shibui, Soichiro, BTSG, Members JCOG
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
Schlagworte:
Adult Clinical Trials
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217838/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou237.57
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