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AT-58 JCOG0911 INTEGRA TRIAL: A RANDOMIZED SCREENING PHASE II TRIAL OF CHEMORADIOTHERAPY WITH INTERFERONβ PLUS TEMOZOLOMIDE VERSUS CHEMORADIOTHERAPY WITH TEMOZOLOMIDE ALONE FOR NEWLY-DIAGNOSED GLIOBLASTOMA
BACKGROUND: Our lab experiments showed that interferonβ (IFNβ) markedly enhanced chemosensitivity to temozolomide (TMZ) via the down-regulation of MGMT transcription. Followed by phase I trial, INTEGRA trial investigated the efficacy of TMZ + IFNβ therapy by a randomized screening design as compared...
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| 發表在: | Neuro Oncol |
|---|---|
| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4217838/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou237.57 |
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