BL-7010 Demonstrates Specific Binding to Gliadin and Reduces Gluten-Associated Pathology in a Chronic Mouse Model of Gliadin Sensitivity

Celiac disease (CD) is an autoimmune disorder in individuals that carry DQ2 or DQ8 MHC class II haplotypes, triggered by the ingestion of gluten. There is no current treatment other than a gluten-free diet (GFD). We have previously shown that the BL-7010 copolymer poly(hydroxyethyl methacrylate-co-s...

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Autores principales: McCarville, Justin L., Nisemblat, Yotam, Galipeau, Heather J., Jury, Jennifer, Tabakman, Rinat, Cohen, Ad, Naftali, Esmira, Neiman, Bela, Halbfinger, Efrat, Murray, Joseph A., Anbazhagan, Arivarasu N., Dudeja, Pradeep K., Varvak, Alexander, Leroux, Jean-Christophe, Verdu, Elena F.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217726/
https://ncbi.nlm.nih.gov/pubmed/25365555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0109972
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