Generation of Atoh1-rtTA transgenic mice: a tool for inducible gene expression in hair cells of the inner ear

Atoh1 is a basic helix-loop-helix transcription factor that controls differentiation of hair cells (HCs) in the inner ear and its enhancer region has been used to create several HC-specific mouse lines. We generated a transgenic tetracycline-inducible mouse line (called Atoh1-rtTA) using the Atoh1 e...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Cox, Brandon C., Dearman, Jennifer A., Brancheck, Joseph, Zindy, Frederique, Roussel, Martine F., Zuo, Jian
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217099/
https://ncbi.nlm.nih.gov/pubmed/25363458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep06885
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