Age-Dependent In Vivo Conversion of Mouse Cochlear Pillar and Deiters' Cells to Immature Hair Cells by Atoh1 Ectopic Expression

Unlike nonmammalian vertebrates, mammals cannot convert inner ear cochlear supporting cells (SCs) into sensory hair cells (HCs) after damage, thus causing permanent deafness. Here, we achieved in vivo conversion of two SC subtypes, pillar cells (PCs) and Deiters' cells (DCs), into HCs by induci...

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Autores principales: Liu, Zhiyong, Dearman, Jennifer A., Cox, Brandon C., Walters, Brandon J., Zhang, Lingli, Ayrault, Olivier, Zindy, Frederique, Gan, Lin, Roussel, Martine F., Zuo, Jian
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359704/
https://ncbi.nlm.nih.gov/pubmed/22573682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0818-12.2012
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