Chondroitin Sulfate is the Primary Receptor for a Peptide-Modified AAV That Targets Brain Vascular Endothelium In Vivo

Recently, we described a peptide-modified AAV2 vector (AAV-GMN) containing a capsid-displayed peptide that directs in vivo brain vascular targeting and transduction when delivered intravenously. In this study, we sought to identify the receptor that mediates transduction by AAV-GMN. We found that AA...

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Vydáno v:Mol Ther Nucleic Acids
Hlavní autoři: Geoghegan, James C, Keiser, Nicholas W, Okulist, Anna, Martins, Inês, Wilson, Matthew S, Davidson, Beverly L
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2014
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217075/
https://ncbi.nlm.nih.gov/pubmed/25313621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2014.50
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