Galectin-1 mediates radiation-related lymphopenia and attenuates NSCLC radiation response

PURPOSE: Radiotherapy (RT) can result in lymphopenia, which has been linked to poorer survival. Here, we test the hypothesis that RT-induced lymphopenia is mediated by a tumor-secreted factor, Galectin-1 (Gal-1), which possesses T-cell pro-apoptotic activities. EXPERIMENTAL DESIGN: Matched Gal-1 wil...

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Bibliografiske detaljer
Main Authors: Kuo, Peiwen, Bratman, Scott V., Shultz, David B., von Eyben, Rie, Chan, Cato, Wang, Ziwei, Say, Carmen, Gupta, Aparna, Loo, Bill W., Giaccia, Amato J., Koong, Albert C., Diehn, Maximilian, Le, Quynh-Thu
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216761/
https://ncbi.nlm.nih.gov/pubmed/25189484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-1138
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