Protection against Lethal Vaccinia Virus Challenge in HLA-A2 Transgenic Mice by Immunization with a Single CD8(+) T-Cell Peptide Epitope of Vaccinia and Variola Viruses

CD8(+) T lymphocytes have been shown to be involved in controlling poxvirus infection, but no protective cytotoxic T-lymphocyte (CTL) epitopes are defined for variola virus, the causative agent of smallpox, or for vaccinia virus. Of several peptides in vaccinia virus predicted to bind HLA-A2.1, thre...

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Bibliographic Details

Published in:	J Virol
Main Authors:	Snyder, James T., Belyakov, Igor M., Dzutsev, Amiran, Lemonnier, François, Berzofsky, Jay A.
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology (ASM) 2004
Subjects:	Vaccines and Antiviral Agents
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC421672/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15194781/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.13.7052-7060.2004
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