Astragalus Polysaccharide Suppresses Doxorubicin-Induced Cardiotoxicity by Regulating the PI3k/Akt and p38MAPK Pathways

Background. Doxorubicin, a potent chemotherapeutic agent, is associated with acute and chronic cardiotoxicity, which is cumulatively dose-dependent. Astragalus polysaccharide (APS), the extract of Astragalus membranaceus with strong antitumor and antiglomerulonephritis activity, can effectively alle...

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Detalhes bibliográficos
Main Authors: Cao, Yuan, Ruan, Yang, Shen, Tao, Huang, Xiuqing, Li, Meng, Yu, Weiwei, Zhu, Yuping, Man, Yong, Wang, Shu, Li, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216718/
https://ncbi.nlm.nih.gov/pubmed/25386226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/674219
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