Biological Analysis of Human Immunodeficiency Virus Type 1 R5 Envelopes Amplified from Brain and Lymph Node Tissues of AIDS Patients with Neuropathology Reveals Two Distinct Tropism Phenotypes and Identifies Envelopes in the Brain That Confer an Enhanced Tropism and Fusigenicity for Macrophages

Complete envelope genes were amplified from autopsy brain tissue of five individuals who had died of AIDS and had neurological complications. Lymph node samples were included for two of the patients. Nineteen different envelope clones from the five patients had distinct V1V2 sequences. Thirteen of t...

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Main Authors: Peters, Paul J., Bhattacharya, Jayanta, Hibbitts, Samantha, Dittmar, Matthias T., Simmons, Graham, Bell, Jeanne, Simmonds, Peter, Clapham, Paul R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2004
Ábhair:
Pathogenesis and Immunity
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC421670/
https://ncbi.nlm.nih.gov/pubmed/15194768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.13.6915-6926.2004
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