Mdm2 and p53 Expression in Radiation-Induced Sarcomas of the Head and Neck: Comparison with De Novo Sarcomas

BACKGROUND: The pathogenesis of radiation-induced sarcomas (RISs) is not well known. In RIS, TP53 mutations are frequent, but little is known about Mdm2-p53 interaction, which is a recent therapeutic target of sarcomas. METHODS: We studied the immunohistochemical expression of Mdm2 and p53 of 8 RISs...

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Detalhes bibliográficos
Main Authors: Song, Min Jeong, Song, Joon Seon, Roh, Jong-Lyel, Choi, Seung-Ho, Nam, Soon Yuhl, Kim, Sang Yoon, Kim, Sung Bae, Lee, Sang-wook, Cho, Kyung-Ja
Formato: Artigo
Idioma:Inglês
Publicado em: The Korean Society of Pathologists and The Korean Society for Cytopathology 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215959/
https://ncbi.nlm.nih.gov/pubmed/25366069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4132/KoreanJPathol.2014.48.5.346
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