Lysophosphatidic acid induces integrin activation in vascular smooth muscle and alters arteriolar myogenic vasoconstriction

In vascular smooth muscle cells (VSMC) increased integrin adhesion to extracellular matrix (ECM) proteins, as well as the production of reactive oxygen species (ROS) are strongly stimulated by lysophosphatidic acid (LPA). We hypothesized that LPA-induced generation of ROS increases integrin adhesion...

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Bibliographic Details
Main Authors: Staiculescu, Marius C., Ramirez-Perez, Francisco I., Castorena-Gonzalez, Jorge A., Hong, Zhongkui, Sun, Zhe, Meininger, Gerald A., Martinez-Lemus, Luis A.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2014
Subjects:
Physiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215695/
https://ncbi.nlm.nih.gov/pubmed/25400583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2014.00413
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