Hydrogen Sulfide Targets EGFR Cys797/Cys798 Residues to Induce Na(+)/K(+)-ATPase Endocytosis and Inhibition in Renal Tubular Epithelial Cells and Increase Sodium Excretion in Chronic Salt-Loaded Rats

Aims: The role of hydrogen sulfide (H(2)S) in renal sodium and water homeostasis is unknown. We investigated whether H(2)S promoted Na(+)/K(+)-ATPase endocytosis via the H(2)S/EGFR/gab1/PI3K/Akt pathway in renal tubular epithelial cells. Results: H(2)S decreased Na(+)/K(+)-ATPase activity and induce...

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Detalhes bibliográficos
Main Authors: Ge, Shun-Na, Zhao, Man-Man, Wu, Dong-Dong, Chen, Ying, Wang, Yi, Zhu, Jian-Hua, Cai, Wen-Jie, Zhu, Yi-Zhun, Zhu, Yi-Chun
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2014
Assuntos:
Original Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215382/
https://ncbi.nlm.nih.gov/pubmed/24684506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2013.5304
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