α-1-Antitrypsin (AAT)–modified donor cells suppress GVHD but enhance the GVL effect: a role for mitochondrial bioenergetics

Hematopoietic cell transplantation is curative in many patients. However, graft-versus-host disease (GVHD), triggered by alloreactive donor cells, has remained a major complication. Here, we show an inverse correlation between plasma α-1-antitrypsin (AAT) levels in human donors and the development o...

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Autors principals: Marcondes, A. Mario, Karoopongse, Ekapun, Lesnikova, Marina, Margineantu, Daciana, Welte, Tobias, Dinarello, Charles A., Hockenbery, David, Janciauskiene, Sabina, Deeg, H. Joachim
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2014
Matèries:
Transplantation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215316/
https://ncbi.nlm.nih.gov/pubmed/25224412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-04-570440
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