Combined therapy with COX-2 inhibitor and 20-HETE inhibitor reduces colon tumor growth and the adverse effects of ischemic stroke associated with COX-2 inhibition

20-Hydroxyeicosatetraenoic acid (20-HETE), Cyp4a-derived eicosanoid, is a lipid mediator that promotes tumor growth, as well as causing detrimental effects in cerebral circulation. We determined whether concurrent inhibition of cyclooxygenase-2 (COX-2) and 20-HETE affects colon tumor growth and isch...

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Detalhes bibliográficos
Main Authors: Zhang, Yi, Hoda, Md Nasrul, Zheng, Xuan, Li, Weiguo, Luo, Pengcheng, Maddipati, Krishna Rao, Seki, Tsugio, Ergul, Adviye, Wang, Mong-Heng
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
Assuntos:
Neural Control
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4214836/
https://ncbi.nlm.nih.gov/pubmed/24990856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00422.2013
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