Malfunctioning of the Iron–Sulfur Cluster Assembly Machinery in Saccharomyces cerevisiae Produces Oxidative Stress via an Iron-Dependent Mechanism, Causing Dysfunction in Respiratory Complexes

Biogenesis and recycling of iron–sulfur (Fe–S) clusters play important roles in the iron homeostasis mechanisms involved in mitochondrial function. In Saccharomyces cerevisiae, the Fe–S clusters are assembled into apoproteins by the iron–sulfur cluster machinery (ISC). The aim of the present study w...

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Detalhes bibliográficos
Main Authors: Gomez, Mauricio, Pérez-Gallardo, Rocío V., Sánchez, Luis A., Díaz-Pérez, Alma L., Cortés-Rojo, Christian, Meza Carmen, Victor, Saavedra-Molina, Alfredo, Lara-Romero, Javier, Jiménez-Sandoval, Sergio, Rodríguez, Francisco, Rodríguez-Zavala, José S., Campos-García, Jesús
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4214746/
https://ncbi.nlm.nih.gov/pubmed/25356756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0111585
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