Harnessing Mechanistic Knowledge on Beneficial Versus Deleterious IFN-I Effects to Design Innovative Immunotherapies Targeting Cytokine Activity to Specific Cell Types

Type I interferons (IFN-I) were identified over 50 years ago as cytokines critical for host defense against viral infections. IFN-I promote anti-viral defense through two main mechanisms. First, IFN-I directly reinforce or induce de novo in potentially all cells the expression of effector molecules...

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Detalhes bibliográficos
Main Authors: Tomasello, Elena, Pollet, Emeline, Vu Manh, Thien-Phong, Uzé, Gilles, Dalod, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4214202/
https://ncbi.nlm.nih.gov/pubmed/25400632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2014.00526
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