Successful anti-SR-BI mAb therapy in humanized mice after challenge with HCV variants with in vitro resistance to SR-BI-targeting agents

Hepatitis C virus (HCV)-induced end-stage liver disease is currently a major indication for liver transplantation. After transplantation the donor liver inevitably becomes infected with the circulating virus. Monoclonal antibodies (mAbs) against the HCV co-receptor scavenger receptor class B type I...

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Detalhes bibliográficos
Main Authors: Vercauteren, Koen, Van Den Eede, Naomi, Mesalam, Ahmed Atef, Belouzard, Sandrine, Catanese, Maria Teresa, Bankwitz, Dorothea, Wong-Staal, Flossie, Cortese, Riccardo, Dubuisson, Jean, Rice, Charles M., Pietschmann, Thomas, Leroux-Roels, Geert, Nicosia, Alfredo, Meuleman, Philip
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4211977/
https://ncbi.nlm.nih.gov/pubmed/24797654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.27196
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