Temporal and Anatomical Host Resistance to Chronic Salmonella Infection Is Quantitatively Dictated by Nramp1 and Influenced by Host Genetic Background

The lysosomal membrane transporter, Nramp1, plays a key role in innate immunity and resistance to infection with intracellular pathogens such as non-typhoidal Salmonella (NTS). NTS-susceptible C57BL/6 (B6) mice, which express the mutant Nramp1(D169) allele, are unable to control acute infection with...

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Autors principals: Loomis, Wendy P., Johnson, Matthew L., Brasfield, Alicia, Blanc, Marie-Pierre, Yi, Jaehun, Miller, Samuel I., Cookson, Brad T., Hajjar, Adeline M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4211889/
https://ncbi.nlm.nih.gov/pubmed/25350459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0111763
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