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Functional Characterization of Sticholysin I and W111C Mutant Reveals the Sequence of the Actinoporin’s Pore Assembly

The use of pore-forming toxins in the construction of immunotoxins against tumour cells is an alternative for cancer therapy. In this protein family one of the most potent toxins are the actinoporins, cytolysins from sea anemones. We work on the construction of tumour proteinase-activated immunotoxi...

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Detalhes bibliográficos
Main Authors: Antonini, Valeria, Pérez-Barzaga, Victor, Bampi, Silvia, Pentón, David, Martínez, Diana, Serra, Mauro Dalla, Tejuca, Mayra
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4211696/
https://ncbi.nlm.nih.gov/pubmed/25350457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0110824
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