Loss of Prkar1a leads to Bcl-2 family protein induction and cachexia in mice

Loss of function mutations in the Prkar1a gene are the cause of most cases of Carney complex disorder. Defects in Prkar1a are thought to cause hyper-activation of PKA signalling, which drives neoplastic transformation, and Prkar1a is therefore considered to be a tumour suppressor. Here we show that...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Gangoda, L, Doerflinger, M, Srivastava, R, Narayan, N, Edgington, L E, Orian, J, Hawkins, C, O'Reilly, L A, Gu, H, Bogyo, M, Ekert, P, Strasser, A, Puthalakath, H
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2014
Sujets:
Original Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4211378/
https://ncbi.nlm.nih.gov/pubmed/25012505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.98
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires