Effectiveness of lithium in subjects with treatment-resistant depression and suicide risk: results and lessons of an underpowered randomised clinical trial

BACKGROUND: As lithium treatment might be effective in reducing the risk of deliberate self-harm (DSH) in adult patients with unipolar affective disorders, we designed a pragmatic randomised trial to assess its efficacy in more than 200 patients with treatment-resistant depression. However, we rando...

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Main Authors: Girlanda, Francesca, Cipriani, Andrea, Agrimi, Emilia, Appino, Maria Grazia, Barichello, Andrea, Beneduce, Rossella, Bighelli, Irene, Bisoffi, Giulia, Bisogno, Alfredo, Bortolaso, Paola, Boso, Marianna, Calandra, Carmela, Cascone, Liliana, Castellazzi, Mariasole, Corbascio, Caterina, Parise, Vincenzo Fricchione, Gardellin, Francesco, Gennaro, Daniele, Hanife, Batul, Lintas, Camilla, Lorusso, Marina, Luca, Antonina, Luca, Maria, Luchetta, Chiara, Lucii, Claudio, Maio, Francesca, Marsilio, Alessandra, Mattei, Chiara, Moretti, Daniele, Nosè, Michela, Occhionero, Guglielmo, Papanti, Duccio, Pecile, Damiano, Percudani, Mauro, Prestia, Davide, Purgato, Marianna, Restaino, Francesco, Romeo, Salvatore, Sciarma, Tiziana, Strizzolo, Stefania, Tamborini, Stefania, Todarello, Orlando, Tozzi, Fiorella, Ziero, Simona, Zotos, Spyridon, Barbui, Corrado
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210495/
https://ncbi.nlm.nih.gov/pubmed/25326163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-0500-7-731
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