Benzene induces gene-duplicating but not gene-inactivating mutations at the glycophorin A locus in exposed humans.

Occupational exposure to benzene is known to cause leukemia, but the mechanism remains unclear. Unlike most other carcinogens, benzene and its metabolites are weakly or nonmutagenic in most simple gene mutation assays. Benzene and its metabolites do, however, produce chromosomal damage in a variety...

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Main Authors: Rothman, N, Haas, R, Hayes, R B, Li, G L, Wiemels, J, Campleman, S, Quintana, P J, Xi, L J, Dosemeci, M, Titenko-Holland, N
Format: Artigo
Sprog:Inglês
Udgivet: 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC42104/
https://ncbi.nlm.nih.gov/pubmed/7732033
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