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Membrane depolarization activates the mitochondrial protease OMA1 by stimulating self-cleavage
Mitochondrial inner membrane fusion depends on the dynamin-related GTPase OPA1 and the function of OPA1 is regulated by proteolytic cleavage. The mitochondrial proteases Yme1L and OMA1 cleave OPA1 at S2 and S1 sites, respectively. Here, we show that OMA1 is cleaved to a short form (S-OMA1) by itself...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4210089/ https://ncbi.nlm.nih.gov/pubmed/24719224 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embr.201338240 |
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