A viral RNA structural element alters host recognition of non-self RNA

Although interferon (IFN) signaling induces genes that limit viral infection, many pathogenic viruses overcome this host response. As an example, 2′-O methylation of the 5′ cap of viral RNA subverts mammalian antiviral responses by evading restriction of Ifit1, an IFN-stimulated gene that regulates...

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Main Authors: Hyde, Jennifer L., Gardner, Christina L., Kimura, Taishi, White, James P., Liu, Gai, Trobaugh, Derek W., Huang, Cheng, Tonelli, Marco, Paessler, Slobodan, Takeda, Kiyoshi, Klimstra, William B., Amarasinghe, Gaya K., Diamond, Michael S.
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4209899/
https://ncbi.nlm.nih.gov/pubmed/24482115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1248465
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