Impact of intrinsic affinity on functional binding and biological activity of EGFR antibodies

Aberrant expression and activation of epidermal growth factor receptor (EGFR) has been implicated in the development and progression of many human cancers. As such, targeted therapeutic inhibition of EGFR, for example by antibodies, is a promising anticancer strategy. The overall efficacy of antibod...

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Hlavní autoři: Zhou, Yu, Goenaga, Anne-Laure, Harms, Brian D., Zou, Hao, Lou, Jianlong, Conrad, Fraser, Adams, Gregory P., Schoeberl, Birgit, Nielsen, Ulrik B., Marks, James D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4209485/
https://ncbi.nlm.nih.gov/pubmed/22564724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-11-1038
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